Selected Publications
Long-lived IgE plasma cells that reside in the spleen contribute to the persistence of the IgE response
Miranda-Waldetario MCG, Gonzalez-Kozlova E, Aguilar EC, Xie L, Hoehn KB, Aranda CJ, Garcia-Carmona Y, Ma EGM, Agudelo ES, Redes J, Curotto de Lafaille MA. Long-lived IgE plasma cells that reside in the spleen contribute to the persistence of the IgE response. Immunity. 2025 Nov 11;58(11):2717-2733.e7. doi: 10.1016/j.immuni.2025.10.011. Epub 2025 Oct 31. PMID: 41175873.
CD23+IgG1+ memory B cells are poised to switch to pathogenic IgE production in food allergy
Ota M, Hoehn KB, Fernandes-Braga W, Ota T, Aranda CJ, Friedman S, Miranda-Waldetario MGC, Redes J, Suprun M, Grishina G, Sampson HA, Malbari A, Kleinstein SH, Sicherer SH, Curotto de Lafaille MA. CD23+IgG1+ memory B cells are poised to switch to pathogenic IgE production in food allergy. Sci Transl Med. 2024 Feb 7;16(733):eadi0673. doi: 10.1126/scitranslmed.adi0673. Epub 2024 Feb 7. PMID: 38324641; PMCID: PMC11008013.
IgG memory B cells expressing IL4R and FCER2 are associated with atopic diseases
Aranda CJ, Gonzalez-Kozlova E, Saunders SP, Fernandes-Braga W, Ota M, Narayanan S, He JS, Del Duca E, Swaroop B, Gnjatic S, Shattner G, Reibman J, Soter NA, Guttman-Yassky E, Curotto de Lafaille MA. IgG memory B cells expressing IL4R and FCER2 are associated with atopic diseases. Allergy. 2023 Mar;78(3):752-766. doi: 10.1111/all.15601. Epub 2022 Dec 19. PMID: 36445014; PMCID: PMC9991991.
Type 2 IgG Memory B Cells and Long-Lived IgE Plasma Cells in the Persistence of Allergy
Miranda-Waldetario MCG, Fernandes-Braga W, Curotto de Lafaille MA. Type 2 IgG Memory B Cells and Long-Lived IgE Plasma Cells in the Persistence of Allergy. Immunol Rev. 2026 Jan;337(1):e70089. doi: 10.1111/imr.70089. PMID: 41508424.
B cell memory of Immunoglobulin E (IgE) antibody responses in allergy
Fernandes-Braga W, Curotto de Lafaille MA. B cell memory of Immunoglobulin E (IgE) antibody responses in allergy. Curr Opin Immunol. 2024 Dec;91:102488. doi: 10.1016/j.coi.2024.102488. Epub 2024 Sep 27. PMID: 39340881.
Oral tolerance to dietary antigens and Foxp3+ regulatory T cells
Miranda-Waldetario MCG, Curotto de Lafaille MA. Oral tolerance to dietary antigens and Foxp3+ regulatory T cells. Immunol Rev. 2024;326:8-16. doi:10.1111/imr.13370
Non-classical B Cell Memory of Allergic IgE Responses
Saunders SP, Ma EGM, Aranda CJ, Curotto de Lafaille MA. Non-classical B Cell Memory of Allergic IgE Responses. Front Immunol. 2019 Apr 26;10:715. doi: 10.3389/fimmu.2019.00715. PMID: 31105687; PMCID: PMC6498404.
IgG1 memory B cells keep the memory of IgE responses
Jin-Shu He, Sharrada Subramaniam, Vipin Narang, Kandhadayar Srinivasan, Sean P. Saunders, Daniel Carbajo, Tsao Wen-Shan, Nur Hidayah Hamadee, Josephine Lum, Andrea Lee, Jinmiao Chen, Michael Poidinger, Francesca Zolezzi, Juan J. Lafaille & Maria A. Curotto de Lafaille. Nature Communications. 8, 641 (2017). DOI: 10.1038/s41467-017-00723-0
A subpopulation of high IL-21-producing CD4(+) T cells in Peyer's Patches is induced by the microbiota and regulates germinal centers
Jones L, Ho WQ, Ying S, Ramakrishna L, Srinivasan KG, Yurieva M, Ng WP, Subramaniam S, Hamadee NH, Joseph S, Dolpady J, Atarashi K, Honda K, Zolezzi F, Poidinger M, Lafaille JJ, Curotto de Lafaille MA. A subpopulation of high IL-21-producing CD4(+) T cells in Peyer's Patches is induced by the microbiota and regulates germinal centers. Sci Rep. 2016 Oct 10;6:34899. doi: 10.1038/srep34899. PMID: 27499025; PMCID: PMC4976330.
The distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response
He JS, Meyer-Hermann M, Xiangying D, Zuan LY, Jones LA, Ramakrishna L, de Vries VC, Dolpady J, Aina H, Joseph S, Narayanan S, Subramaniam S, Puthia M, Wong G, Xiong H, Poidinger M, Urban JF, Lafaille JJ, Curotto de Lafaille MA. The distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response. J Exp Med. 2013 Nov 18;210(12):2755-71. doi: 10.1084/jem.20131539. Epub 2013 Nov 11. PMID: 24218137; PMCID: PMC3832920.
Sequential class switching is required for the generation of high affinity IgE antibodies
Xiong H, Dolpady J, Wabl M, Curotto de Lafaille MA, Lafaille JJ. Sequential class switching is required for the generation of high affinity IgE antibodies. J Exp Med. 2012 Feb 13;209(2):353-64. doi: 10.1084/jem.20111941. Epub 2012 Jan 16. PMID: 22249450; PMCID: PMC3280879.
Unique maturation program of the IgE response in vivo
Erazo A, Kutchukhidze N, Leung M, Christ AP, Urban JF Jr, Curotto de Lafaille MA, Lafaille JJ. Unique maturation program of the IgE response in vivo. Immunity. 2007 Feb;26(2):191-203. doi: 10.1016/j.immuni.2006.12.006. Epub 2007 Feb 8. PMID: 17292640; PMCID: PMC1892589.